North Yorkshire Police were called by the Yorkshire Ambulance Service, which had attended a serious assault at an address in Eastborough on Wednesday night.
Despite the efforts of paramedics a man in his 30s was pronounced dead at the scene.
Four men were arrested a short time later at an address on Queen’s Terrace, Scarborough. They are being questioned by detectives.
More top news
Emma Jesson brings you Sunday night's forecast
Cold and clear with widespread frost on Sunday night. Sunny Monday then showers
A number of Britons are feared stranded on Mount Everest after the Nepal earthquake triggered a deadly avalanche on Saturday.