Durham Tees Valley airport have announced they are "moving away" from mainstream holiday charter programmes from summer 2014.
Tour operators affected are Thompson/First Choice and Balkan Holidays.
Flights to Schipol in Amsterdam, operated by KLM, and Aberdeen, operated by Eastern Airways, will not be affected.
Flybe flights operated on behalf of CITS to Jersey will also remain in place.
Anyone who has booked holiday flights to Palma, Ibiza or Bulgaria for 2014 flying from Durham Tees Valley Airport is advised to contact their tour operator or travel agent for advice.