James Ramsbotham, Chief Executive of the North East Chamber of Commerce, says companies like Nissan need to know whether the UK will remain in the EU.
The head of the Japanese car company, Carlos Ghosn, has claimed they would "reconsider" their position if the UK left the EU.
This would threaten jobs at Nissan's plant in Sunderland, which employs 6,500 people.
More top news
Spennymoor FC were visiting Newton Aycliffe on Tuesday evening and refused to play the second half of the match.
Eric Thomson says within hours of the stem cell treatment he began to regain some control of his body.
The programme for looked-after children replaces traditional council-run care homes with hubs. Its been recommended in a national report.