Neil Foster, Northern TUC, has said that the region's economy would be left shaken if Nissan left the UK. It comes after the chief executive of Nissan said he would reconsider the car maker's future in the UK if it left the European Union.
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A decision will be announced on the fate of three GP surgeries in Hartlepool later.
The UK only managed to rank 20th on the World Economic Forum's (WEF) index of nations - a slide from 9th position in 2006.
"Last season is fading from view in the rear-view mirror with bright skies ahead for the rest of the season."