Retailers trading from inside shopping parades, known as InShops, have to find new premises before this Friday (January 17th) as the chain is going into liquidation.
InShop centres in Consett, Bishop Aukland and Thornaby on Teesside are all affected.
It means around 45 small businesses will close down unless they can find a new place to trade from.
ITV has tried to contact the owner of InShop's but they decline to comment.
More top news
Teaching Assistants in County Durham have staged a demonstration outside County Hall, in a long-running dispute over plans to cut their pay.
The number of jobs set to go at Sunderland AFC won't be dictated by whether or not the club are relegated from the Premier League.
Production has started on Nissan Sunderland's new extra-large press. The £37 million project can create 2.5 million car panels a year.