Retailers trading from inside shopping parades, known as InShops, have to find new premises before this Friday (January 17th) as the chain is going into liquidation.
InShop centres in Consett, Bishop Aukland and Thornaby on Teesside are all affected.
It means around 45 small businesses will close down unless they can find a new place to trade from.
ITV has tried to contact the owner of InShop's but they decline to comment.
More top news
Often very windy, especially as we head into Sunday, with rain or showers. Met Office 'Be Aware' warnings have been issued
Here is our essential guide to all things Christmas in the North East.
Trainees work with life sized childbirth simulators