Loic Remy and Luuk de Jong, who've been on loan at Newcastle United, will return to their parent clubs next season.
French international striker Remy was the Magpies top goal scorer last season, with 14 goals in just 27 games. He will return to Queens Park Rangers.
De Jong was a January loan signing from German side Borussia Monchengladbach. He made 12 appearances for Newcastle.
Michael Richardson, Steven Logan, Brandon Miele and Jonathan Mitchell have also been released ahead of the 2014/15 season.
Manager Alan Pardew said: 'I would like to thank each of these players for the effort, attitude and application they have put in while at the Club.'
More top news
Emma brings you Sunday's forecast for the Tyne Tees region
The remaining two anti-fracking protestors who climbed a rig at a live well site in Kirby Misperton, North Yorkshire, have been removed.
The incident near Fenrother involved a Honda Civic travelling south from Scotland and a Seat Ibiza travelling north from Morpeth.