Baroness Tanni Grey-Thompson on Thursday became the fourth member of the London 2017 Athletics World Championships board to resign in the last six weeks.
The 11-time Paralymic wheelchair champion, who lives in Eaglescliffe on Teesside, said her role on the organising committee had become "tokenistic".
London is preparing to host the International Paralympic Committee Athletics World Championships alongside the IAAF event.
The 11-time Paralympic champion felt she was not making progress with her contribution.
Grey-Thompson said, according to the BBC: "I got to the point where I was going round in circles. It needs to be someone else because I don't feel I was having the impact in terms of taking that discussion on."
A statement from London 2017 said Grey-Thompson had resigned to focus on her work in the House of Lords.
It read: "London 2017 can confirm that Baroness Tanni Grey-Thompson has stepped down from her role on the board of 2017. She has taken the decision in order to dedicate her full attention to her work in the House of Lords, and her new responsibilities leading the development of a Duty of Care for Sport and the protection of those most vulnerable in society."