Pope Benedict XVI criticised the 50-year-old US trade embargo on Cuba as he wrapped up a three-day visit to the island, urging reconciliation and greater freedoms.
He said: "May no one feel excluded ... from taking up this exciting search for his or her basic freedoms, or excused from this by indolence or lack of material resources, a situation which is worsened when restrictive economic measures, imposed from outside the country, unfairly burden its people."
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It ends a political standoff that briefly saw Yahya Jammeh and Adama Barrow claiming leadership of this tiny West African nation.
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The historic moment was watched by 500 people in the Church in Wales who cheered after the ceremony.