At about 10.15pm on Saturday police were called to Bury New Road at its junction with Sherborne Street after reports of a crash.
Police officers went to the scene, where the 32-year-old man and 37-year-old woman died but the teenagers were taken to Hope Hospital, where they are being treated.
It is a devastating tragedy for this family and also for the Greater Manchester community at large. Manchester City Football Club offers its heartfelt condolences to the family and all affected by the events of yesterday evening.
The situation is subject to an extensive investigation by Greater Manchester Police and therefore we are unable to make specific comment on the incident itself at this time.
More top news
The number of children in care has increased to its highest level for nearly 25 years, the Government's spending watchdog has said.
Abuse victims are being put through "torture" by the pace at which the Government's inquiry into abuse is progressing, an MP has said.
The number of diabetic and severely overweight patients having weight loss surgery needs to triple to help the future of the NHS, Nice said.