At about 10.15pm on Saturday police were called to Bury New Road at its junction with Sherborne Street after reports of a crash.
Police officers went to the scene, where the 32-year-old man and 37-year-old woman died but the teenagers were taken to Hope Hospital, where they are being treated.
– A Manchester City spokeswoman
It is a devastating tragedy for this family and also for the Greater Manchester community at large. Manchester City Football Club offers its heartfelt condolences to the family and all affected by the events of yesterday evening.
The situation is subject to an extensive investigation by Greater Manchester Police and therefore we are unable to make specific comment on the incident itself at this time.