At about 10.15pm on Saturday police were called to Bury New Road at its junction with Sherborne Street after reports of a crash.
Police officers went to the scene, where the 32-year-old man and 37-year-old woman died but the teenagers were taken to Hope Hospital, where they are being treated.
It is a devastating tragedy for this family and also for the Greater Manchester community at large. Manchester City Football Club offers its heartfelt condolences to the family and all affected by the events of yesterday evening.
The situation is subject to an extensive investigation by Greater Manchester Police and therefore we are unable to make specific comment on the incident itself at this time.
More top news
A British jihadi who has lost two of his brothers in Syria has told ITV News that he intends to stay and fight until he is also killed.
A doctor who worked in paediatrics in hospitals across Greater Manchester has admitted a string of child sex offences.
An artist has created a tribute portrait of late presenter Lynda Bellingham made entirely from beef Oxo cubes.