Belfast man Michael McKillop has won the men's 1500 metre T37 final in a record breaking time of 4:08.11. McKillop runs for Ireland, who are currently 12th in the medals table.
Great Britain's Dean Miller came seventh in running the track in 4:21.57.
Ellie Simmonds broke her own world record to secure her second gold medal of London 2012 in the SM6 200 metres individual medley.
ParalympicsGB's medal hopes on day five lie with Lee Pearson, Ellie Simmonds and Mickey Bushell.