From Monday, women across the UK who are between 28 and 38 weeks pregnant will be offered the vaccination.
The drug which is to be administered, called Repevax, has raised safety fears, coming with the advice: "The use of this combined vaccine is not recommended in pregnancy".
But the Joint Committee on Vaccination and Immunisation (JCVI) - the independent panel of vaccine experts which advises the Government - said that it has "no concerns" about the safety of the vaccine, which protects against whooping cough, diphtheria, tetanus and polio.
Chief Medical Officer Professor Dame Sally Davies, the Government's principal medical adviser, said:
I know that pregnant women can feel very vulnerable about protecting themselves and their baby's health and clearly we don't want pregnant women taking medication of any form unless it's necessary. But I can't stress enough that this is an important thing that pregnant women can do to protect their baby.
More top news
A Bolton chemistry teacher is to be sentenced today after admitting terror offences - with police claiming he wanted to join Islamic State.
Average household incomes have returned to around the levels they were at before the financial crisis hit, new analysis indicates.
Figures uncovered by a Freedom of Information request reveal one university leader received £623,000 in 2013/14.