The mandate is the first ever "contract" between the Government and the health service, which ministers said allows it to be held to account.
Jeremy Hunt said NHS priorities included reducing avoidable mortality, improving patient experience and helping patients with long-term conditions such as dementia and diabetes.
The Government believes the new mandate document will give frontline health professionals more power and independence to deliver care.
More top news
A British man was grounded in Bermuda as his new wife continued to Cuba without him after drunkenly threatening the flight crew.
A petition calling for Tony Blair's anti-poverty award to be taken back has gained more than 90,000 signatures.
American scientist, who was the co-discoverer of DNA, is offering his Nobel Prize medal at auction and it could sell for up to $3.5 million.