The mandate is the first ever "contract" between the Government and the health service, which ministers said allows it to be held to account.
Jeremy Hunt said NHS priorities included reducing avoidable mortality, improving patient experience and helping patients with long-term conditions such as dementia and diabetes.
The Government believes the new mandate document will give frontline health professionals more power and independence to deliver care.
More top news
A historic night in Philadelphia saw mixed emotions as a bitter rivalry was settled before Bill Clinton made his pitch for his wife to lead.
The Labour leadership contender promised to focus on 'equality of outcome' rather than the 'equality of opportunity' pursued under Blair.
A dull and wet start with some sunshine in south-east Scotland and north-east England.