The mandate is the first ever "contract" between the Government and the health service, which ministers said allows it to be held to account.
Jeremy Hunt said NHS priorities included reducing avoidable mortality, improving patient experience and helping patients with long-term conditions such as dementia and diabetes.
The Government believes the new mandate document will give frontline health professionals more power and independence to deliver care.
More top news
The man identified as the Islamic State militant known as "Jihadi John" was a "popular" schoolboy who loved Manchester Utd and S Club 7.
Everton, the only British side left in the Europa League, have been handed a tough tie against Dynamo Kyiv in the last 16 round
Ukip remains the party most trusted to control immigration despite more people seeing them as racist, a ComRes/ITV News poll has found.