The mandate is the first ever "contract" between the Government and the health service, which ministers said allows it to be held to account.
Jeremy Hunt said NHS priorities included reducing avoidable mortality, improving patient experience and helping patients with long-term conditions such as dementia and diabetes.
The Government believes the new mandate document will give frontline health professionals more power and independence to deliver care.
More top news
British soldiers will join troops from some 30 countries who work in the country.
The demand comes after the Prime Minister urged a "grown up" relationship between her government and the devolved administrations.
The rapper failed to make it to London in time as he had problems with his passport.