Dramatic footage uploaded by activists shows panicked families and a number of children attempting to flee the town of Ras al-Ain.
One little girl is seen running down a street alone before being lifted up by a man who attempts to locate her missing family.
Elderly men are seen attempting to take cover in bombed out buildings, whilst the sound of fighter jets is heard overhead.
The Associated Press said the activist footage was "consistent with their own reporting" from the area.
Thousands more refugees pour across the border to escape the war in Syria, whilst Turkey says the conflict is threatening their security.
A suggestion that David Cameron has gone "out on a limb" over Syria has been rejected by his official spokesman.