Labour's Lucy Powell has been elected MP for Manchester Central with a majority of 9,936 votes.
In second place was the Liberal Democrat candidate Marc Ramsbottom, who secured 1,571 votes.
The turnout of 18.16% was reportedly the lowest in a parliamentary by-election since the Second World War.
The post-war record until now for the lowest turnout is believed to be 19.9% in 1999 in the seat of Leeds Central.
Ed Miliband claimed that Middle England was turning its back on David Cameron, after Labour won the Corby by-election on a 12.7% swing.
Labour today held Manchester Central and Cardiff South and Penarth constituency seats in their respective by-elections.