The Foreign Secretary William Hague has said "the UK is deeply concerned at emerging reports of a bomb attack on a bus in Tel Aviv":
At this time our thoughts are with the individuals and families affected.
Details of what happened are still unclear but if this was a terrorist attack we condemn it unreservedly.
We are clear that terrorists must not be allowed to set the agenda.
This shocking violence further underlines the urgent need for an immediate de-escalation of violence and a full ceasefire.
We urge all those involved to do everything they can to give maximum support to Egyptian-led efforts to allow them to succeed.
Today's bombing in Tel Aviv is reminiscent of six years ago and could mark a serious escalation in the conflict.
A truce in Gaza suits all sides but none of the groups seem interested in a long-lasting solution.
A complex system of air defences has been instrumental in protecting Israel's population from incoming rockets.