The Labour leader Ed Miliband has pressed the Prime Minister to explain how pressure can be put on Israel and Hamas to join meaningful negotiations to bring about a ceasefire.
David Cameron said that he has spoken to both sides in the conflict but that peace can only come about with "Israelis and Palestinians sitting down and negotiating".
He said this was a higher priority than taking action through the United Nations.
Today's bombing in Tel Aviv is reminiscent of six years ago and could mark a serious escalation in the conflict.
A truce in Gaza suits all sides but none of the groups seem interested in a long-lasting solution.
A complex system of air defences has been instrumental in protecting Israel's population from incoming rockets.