Police blamed terrorists for the attack in Tel Aviv, which happened as the bus drove along a street near the Israeli Defence Ministry. The explosion could jeopardise international efforts to agree a ceasefire between Israel and Gaza, as Nina Nannar explains.
Today's bombing in Tel Aviv is reminiscent of six years ago and could mark a serious escalation in the conflict.
A truce in Gaza suits all sides but none of the groups seem interested in a long-lasting solution.
A complex system of air defences has been instrumental in protecting Israel's population from incoming rockets.