Sir Ranulph and his five-man team will cross the continent during winter over a six-month period. Going with them will be two machines to help carry their equipment.
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Temperatures will reach around 28 Celsius (82F) at their highest.
A minute's silence will be observed at 11am on Thursday in remembrance of those who lost their lives in the Manchester Arena attack.
New research has found those who consumed two cups had a 35% reduced risk, and for those who drank five cups, the risk halved.