The last Sky At Night programme was broadcast on Monday.
Sir Patrick has only missed one episode since it began, on 24th April 1957, when he was struck down by food poisoning.
His trademark monocle, unique delivery and occasional performances on the xylophone made him a familiar target for satirists and impressionists, but his scientific credentials were never in doubt.
The show's guests have included many prominent scientists as well as Goon Show star Michael Bentine and astronauts Neil Armstrong and Buzz Aldrin.
But the demands of live television have led to the occasional blooper, with Sir Patrick famously once swallowing a fly live on air.
More top news
The former US president has Tweeted six of the top 10 most liked tweets ever - with current president Donald Trump not making the list.
By the time all the dead are counted, it will have grown to a great chorus of grief, Africa Correspondent John Ray reports.
For years we’ve been told to stay out of the hot summer sun. So how much sun is too much? Kylie Pentelow looks at the latest advice.