The last Sky At Night programme was broadcast on Monday.
Sir Patrick has only missed one episode since it began, on 24th April 1957, when he was struck down by food poisoning.
His trademark monocle, unique delivery and occasional performances on the xylophone made him a familiar target for satirists and impressionists, but his scientific credentials were never in doubt.
The show's guests have included many prominent scientists as well as Goon Show star Michael Bentine and astronauts Neil Armstrong and Buzz Aldrin.
But the demands of live television have led to the occasional blooper, with Sir Patrick famously once swallowing a fly live on air.
More top news
A pair of cyclists made the shocking discovery of a baby at the bottom of a drain in Australia.
A weather warning is in place across the south-east with heavy rainfall expected. Elsewhere there will be plenty of sunshine around.
Britain's Lewis Hamilton will join an elite club of double Formula One champions if he can secure a top-two finish in Abu Dhabi today.