The last Sky At Night programme was broadcast on Monday.
Sir Patrick has only missed one episode since it began, on 24th April 1957, when he was struck down by food poisoning.
His trademark monocle, unique delivery and occasional performances on the xylophone made him a familiar target for satirists and impressionists, but his scientific credentials were never in doubt.
The show's guests have included many prominent scientists as well as Goon Show star Michael Bentine and astronauts Neil Armstrong and Buzz Aldrin.
But the demands of live television have led to the occasional blooper, with Sir Patrick famously once swallowing a fly live on air.
More top news
ITV Border Political Editor Peter MacMahon says it's far too early to call this referendum.
A World War Two veteran has told ITV News he has fulfilled a boyhood dream by voting for an independent Scotland.
Keep on top of the referendum results as they are announced from 32 counting stations across Scotland.