The last Sky At Night programme was broadcast on Monday.
Sir Patrick has only missed one episode since it began, on 24th April 1957, when he was struck down by food poisoning.
His trademark monocle, unique delivery and occasional performances on the xylophone made him a familiar target for satirists and impressionists, but his scientific credentials were never in doubt.
The show's guests have included many prominent scientists as well as Goon Show star Michael Bentine and astronauts Neil Armstrong and Buzz Aldrin.
But the demands of live television have led to the occasional blooper, with Sir Patrick famously once swallowing a fly live on air.
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Duncan Jones tweeted: "1 month since dad died today. Made this card for him at Christmas. Due in June. Circle of life. Love you, granddad."
More than 10 days after his body was found, Richard Cole's family claim they are still in the dark over the circumstances of his death.
A cold and frosty start, then staying largely dry with plenty of sunshine.