Pope Benedict XVI told pilgrims gathered in Vatican City's St. Peter's Square that he was "deeply saddened by Friday's senseless violence in Newtown, Connecticut".
The pontiff said, "I assure the families of the victims, especially those who lost a child, of my closeness in prayer. May the God of consolation touch their hearts and ease their pain".
"Upon those affected by this tragedy, and upon each of you, I invoke God's abundant blessings!", he added.
More top news
Prime Minister plans a whistle-stop charm offensive with EU leaders this week.
Thriller writer Anthony Horowitz is at the helm of the latest Bond book, which is based on an unfilmed Ian Fleming TV script.
Actress who plays iconic Daenerys Targaryen admitted she didn't want to become typecast for nudity.