Pope Benedict XVI told pilgrims gathered in Vatican City's St. Peter's Square that he was "deeply saddened by Friday's senseless violence in Newtown, Connecticut".
The pontiff said, "I assure the families of the victims, especially those who lost a child, of my closeness in prayer. May the God of consolation touch their hearts and ease their pain".
"Upon those affected by this tragedy, and upon each of you, I invoke God's abundant blessings!", he added.
More top news
Storm Doris will bring wet and very windy conditions across the UK over the next 24 hours.
An ITV Tonight investigation found more than half of women surveyed between the ages of 18 and 34 have been sexually harassed in public.
Katy Perry performed her new single surrounded by two giant skeletons seemingly modeled on Donald Trump and Theresa May.