The car crash that has resulted in the deaths of two girls happened on the A47 near Wisbech on the border between Norfolk and Cambridgeshire, according to police.
All five occupants of the black Ford Focus were taken to the Queen Elizabeth Hospital in King's Lynn, where the girls died from their injuries.
The other three occupants of the car remain in hospital, although police said their injuries are not believed to be serious.
More top news
A five-year-old boy whose surprise meeting with "Spiderman" became an online hit has died.
It's going to feel very cold in parts today, with temperatures between 3C and 6C before falling to as low as -6C in some areas overnight.
A son paid off his parents' mortgage for Christmas - reducing them to tears.