Addressing the nation President Assad said Syria "will not have a dialogue with a puppet made by the West".
The remarks were his first in public since a Russian television interview in November when he pledged to stay in Syria and fight to the death if necessary.
A 21-month uprising against Assad has become a civil war that the UN says has killed 60,000 people.
More top news
More than one in four Britons aged 55 and over financially support their child or other dependents to get on to the property ladder.
Known as 'spice' and 'black mamba', the so-called legal high is suspected of contributing to deaths in male and female institutions.
Prince Harry will launch the countdown to the 2017 Invictus Games in Canada - as he gears up for the this year's event in Florida.