Addressing the nation President Assad said Syria "will not have a dialogue with a puppet made by the West".
The remarks were his first in public since a Russian television interview in November when he pledged to stay in Syria and fight to the death if necessary.
A 21-month uprising against Assad has become a civil war that the UN says has killed 60,000 people.
More top news
Jamie Oliver turned down the offer of playing a hobbit in the movie adaptation of the book by JRR Tolkien, the TV chef has revealed.
Children are being put at risk as 11% of posts for permanent children's social workers remain unfilled, experts have warned.
A Network Rail boss who presided over the Christmas trains chaos will not receive a bonus of more than £300,000 when he leaves in February