Vince Cable will urge David Cameron not to take a "dangerous gamble" with the national interest today as the Liberal Democrats mount pressure over Europe.
On the eve of the Prime Minister's expected announcement of a future referendum on UK membership of the EU, he will reinforce warnings the strategy risks damaging economic recovery.
Any effort to negotiate large-scale exits from existing EU powers would make it "next to impossible" to safeguard Britain's best interests in the single market, the Business Secretary will suggest.
Centrica's boss warns an EU referendum risks "total destabilisation" for businesses; the Next chief suggests that view is "scaremongering."
There will be sympathy, yes. But will they agree with him? No.
Conservative MPs said their "achievable" proposals to change Britain's role in Europe do not represent an ultimatum to the Prime Minister.