Rescue workers walked along a four-mile stretch of the M6 in Lancashire overnight to check on the condition of drivers.
A diabetic man was taken to Royal Blackburn Hospital, while an ambulance taking a female patient to Royal Preston Hospital had to be dug out of the snow by Bowland Pennine Mountain Rescue team.
ITV News Reporter Nick Thatcher reports:
The Environment Agency has issued flood warnings and flood alerts across the UK.
Milder temperatures overnight will cause snow to thaw rapidly, with heavy rain expected to bring the risk of flooding in England and Wales.
Granada's Programme Editor Andrew Rigby was caught in the M6 snow chaos. Here he describes his nightmare journey home.