A spokesman for Ladbrokes has said the firm is "not prepared to offer long odds" on the HS2 line being subject to delays, alterations and cancellations.
The bookmaker is currently offering 4/5 that there will be delays when it comes to the opening of the service.
The government expects to complete the first phase of the high speed route from London to Birmingham by 2026, with the Manchester and Leeds extension being finished by 2033.
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Michael Danaher, 50, killed historian and book dealer Adrian Greenwood at his home over a £50,000 first edition copy of Wind In The Willows.
The former Cardiff South and Penarth parliamentary candidate joins Suzanne Evans, Paul Nuttall and Raheem Kassam in the race.
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