The sign, which had covered the length of the shop front, fell on to the pavement on a main road in Camden, north London.
Police erected a forensic tent on the pavement to cover the place where the man was killed, and cordoned off the surrounding area.
Ioana Nita, 21, was working at a nearby restaurant when the accident happened.
"I'm shocked. We heard a very loud noise. Me and a colleague went outside and saw the guy lying on the floor," she said.
"Five guys picked up the sign and it was put on the side. His hands were covered in blood and he wasn't moving.
"Lots of people were in a circle around him, then the ambulance arrived and they were trying to get him back to life, pressing on his heart."
Ken Osbourne, 28, who works at the nearby Woody Grill restaurant, said: "I saw the guy lying down in the road, covered in blood.
"The main impact was clearly on his head. I saw them trying to resuscitate him in the back of the ambulance."
More top news
McDonald's in Japan will resume serving large portions of French fries in January after a labour dispute in the US disrupted supply.
More than four in 10 cases of cancer in the UK could be avoided if people made changes to their lifestyle, Cancer Research says.
Services took place in Indonesia, Thailand, Sri Lanka and India on the 10th anniversary of the tsunami which claimed 230,000 lives.