David Cameron said: "I send my best wishes to Pope Benedict following his announcement today. He has worked tirelessly to strengthen Britain's relations with the Holy See.
"His visit to Britain in 2010 is remembered with great respect and affection. He will be missed as a spiritual leader to millions."
So, we're all shocked at the resignation of the Pope, but what happens next?
Pope Benedict XVI has made the announcement that he will resign as the head of the Roman Catholic Church due to his "advanced age."
Who will follow in Pope Benedict's footsteps? Is it time for an African pope?