In the latest in ITV News' series of reports, From The Heart focuses on the extraordinary medical technology that keeps patients alive - while they wait for the heart transplant they so desperately need.
As ITV News' medical editor Lawrence McGinty reports from Papworth Hospital, the shortage of donors means that it is sometimes a long wait:
Vincenzo has been transformed from a patient so sick he could not wash his face to a man who strides confidently with a gleam in his eye.
A look at organ donation rates around the world and how the UK compares.
In a one hour special the Tonight programme investigates the lives of the 10,000 Brits on waiting lists for an organ transplant.