An explosion shook central Damascus residents said, with state media reporting a "terrorist explosion" had caused casualties.
Syrian television said the explosion was in the Mazraa district of the capital. The Syrian Observatory for Human Rights, which monitors violence in the country, said initial reports suggested a building of the ruling Baath Party was targeted.
More top news
The man who sold himself to Americans as the ultimate deal-maker has had to back down over his planned healthcare reforms.
A coalition airstrike reportedly struck a shelter used by those fleeing the militants last week leaving over 100 dead.
High pressure gives settled weather across the UK.