According to the paper, nearly 2,000 nurses, managers and other senior NHS staff were spoken to, with more than 90 per cent of them saying he should step down.
Speaking to the Daily Mail, Roy Liley, a health policy analyst said:
It is clear he no longer enjoys the support of front-line staff.
As stories of quality horrors, bullying and service dislocation emerge, it would seem time to recognise Sir David's huge contribution to the NHS in the past but make it clear he is not the man to take the NHS into the future.
Last night David Cameron defended Sir David, when he was questioned by reporters in India.
A public inquiry has blamed a failure 'at every level' of the NHS for the abuses at Stafford Hospital that resulted in hundreds of deaths.
The chair of the inquiry into Mid Staffordshire NHS made 290 recommendations to prevent the 'disaster' of Stafford Hospital occurring again.
Managers at Stafford Hospital accept that there were problems on some of the wards. But they say it's now one of the best in the country.