At least a further three people were hospitalised, including a passenger from the Maserati.
A tourist who witnessed the aftermath of the crash told KLAS-TV that the burning taxi looked like a fireball.
More people may be hurt, Sergeant Sheahan said.
It is the latest in a series of violent actions on the tourist corridor since the beginning of the year. Two people were critically wounded in a shooting at a parking garage 6th February, and a tourist was stabbed in an elevator at The Hotel at Mandalay Bay ten days later.
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Police are trying to find the driver of the car following the incident in Kingfisher Close, Brownhills.
An unnamed man died at the scene, while a woman was pronounced dead after being taken to St George's Hospital, Tooting, south-west London.
Eastern areas will see a few showers coming in on the northeasterly breeze