A car bomb exploded outside a mosque in Karachi, Pakistan, killed at least 45 people and wounded more than 149, a senior official told the Associated Press.
No one has taken responsibility for the bombing, that took place outside a Shiite mosque as people were leaving evening prayers in Pakistan's largest city.
Initial reports suggested the bomb was rigged to a motorcycle, but a police official told the Associated Press that an estimated 220 pounds of explosives was planted in a car.
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Many affected were seen burying their faces in their hands and people flooded from the room in tears.