A car bomb exploded outside a mosque in Karachi, Pakistan, killed at least 45 people and wounded more than 149, a senior official told the Associated Press.
No one has taken responsibility for the bombing, that took place outside a Shiite mosque as people were leaving evening prayers in Pakistan's largest city.
Initial reports suggested the bomb was rigged to a motorcycle, but a police official told the Associated Press that an estimated 220 pounds of explosives was planted in a car.
More top news
Brothers Andy and Jamie Murray have beaten Belgian pair David Goffin and Steve Darcis to take a 2-1 lead in the Davis Cup Final
Protesters gathered outside Downing Street to urge MPs to vote down plans to bomb the war-torn country
Strong winds, heavy rain and snow forecast across the UK