Asked what changes were required to implement the recommendations of the Francis Report on Mid Staffordshire Hospital, Sir David Nicholson said: "This is a significant change programme for the NHS from literally top to bottom.
"It's from setting out basic standards that patients and everyone can understand and assessing and inspecting again against them."
More top news
Major changes to the care system introduced today have already come under fire from charities
During a visit to the crash site, the boss of Lufthansa has avoided reporters' questions about the co-pilot's known depression.
One Leicestershire mother managed to get a shop worth £140.27 for just 39p, Jennifer Drew told Good Morning Britain how.