The Public and Commercial Services union said almost 250,000 workers will take part in a rolling series of walkouts and protests as it steps up its campaign against budget cuts.
A 24-hour strike will be held on March 20, the day Chancellor George Osborne presents the Budget to Parliament.
Further national stoppages will be held, of varying durations and targeting different parts of the civil service, with dates to be announced at a later stage.
Other forms of disruptive industrial action will also be held, and the PCS said it will seek to co-ordination with other unions on pay and pensions.
More top news
It will be a cloudy and at times damp morning across much of the UK, apart from the far west where it will be dry and bright.
Barack Obama has returned to the political spotlight, campaigning for Democratic candidates ahead of upcoming elections.
The prime minister said there was a "clear and urgent imperative" to give new impetus to stalled negotiations.