The Deputy Prime Minister will hail the by-election victory in Eastleigh as proof that the Lib Dems can succeed as a party of government.
He will also dismiss the "myth" that being in coalition has undermined their identity or ability to fight the Conservatives.
The rallying cry comes in a keynote speech to the Lib Dem spring conference in Brighton.
The leadership has been eager to use the gathering to move on from damaging allegations of sexual harassment by Lord Rennard - which he denies - and the conviction of former Cabinet minister Chris Huhne.
More top news
Olivia's mum is to marry her fiance this weekend, and the couple are dedicating every detail of the day to Olivia.
At the Royal Berkshire Hospital in Reading, ITV News met the beds manager who is tasked with finding enough beds for the day's patients.
Windy, wet and mild