The Deputy Prime Minister will hail the by-election victory in Eastleigh as proof that the Lib Dems can succeed as a party of government.
He will also dismiss the "myth" that being in coalition has undermined their identity or ability to fight the Conservatives.
The rallying cry comes in a keynote speech to the Lib Dem spring conference in Brighton.
The leadership has been eager to use the gathering to move on from damaging allegations of sexual harassment by Lord Rennard - which he denies - and the conviction of former Cabinet minister Chris Huhne.
More top news
In the run-up to the Rio Olympic Games, ITV News speaks to four Olympic hopefuls in Team GB. Today we profile gymnast Claudia Fragapane.
The mother-in-law of Formula One billionaire Bernie Ecclestone has been kidnapped in Sau Paulo according to Brazilian media reports.
Four "siblings" of Dolly the sheep are in good health, raising hopes that the cloning process does not affect physical well-being.