Judgment is being handed down by Mr Justice Ouseley at London's High Court. Whatever the judge decides, appeals against his decisions are almost certain to be taken to the Court of Appeal.
Key accusations include that the Government has unlawfully failed to undertake a strategic environmental assessment of the entire project before giving the go-ahead, or to arrange a consultation process "that allows informed responses on the true merits and demerits of the proposals".
There is also a dispute over the compensation arrangements being put in place for homeowners living near the HS2 line.
Some 172,000 properties within 1km of the first phase are reported to be affected by "a generalised blight" since the proposals were announced.
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The controversial procedure involved nuclear DNA from the mother, mitochondrial DNA from a donor, and the father's sperm.
The move comes amid a boycott of the paper in Liverpool due to its controversial coverage of the 1989 Hillsborough disaster.
Glasgow East MP Natalie McGarry has been charged in connection with alleged fraud offences.