MS sufferer Alyson Fletcher has lived in her home in Dunstable for 47 years but she said she will need to find an extra £100 a month when the Government's so-called 'bedroom tax' is introduced.
Speaking to ITV's Daybreak she said if she had to move again and make modifications to her next home she would be looking at a cost of "around £17,000".
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David Cameron said the measure, which will save £4 million by 2020, showed a commitment to his "all in this together" approach.
The party has dropped its opposition to an in/out referendum on EU membership and now supports a vote, acting leader Harriet Harman said.