David Miliband told ITV News "I am leaving politics" as he steps down as an MP to take on a charity role based in New York.
He admitted life had been tough since losing the leadership election to his brother Ed.
Political Editor Tom Bradby began by asking him whether the move means an end to his political career:
David Miliband was nearly Prime Minister, and nearly Labour party leader, but his brother's rise has led him to take a back seat.
David Miliband will resign as an MP to take up a job in America, a move which is set to be announced today.