In a statement, the Prime Minister of the Czech Republic Petr Necas said he was "deeply hit by the tragedy of the gas explosion", the Associated Press reports.
It is not certain what caused the blast in Divadelni Street in the central Prague but it was likely to be a natural gas explosion, police spokesman Tomas Hulan said.
More top news
There is a snow and ice warning in force for much of the UK tomorrow, but temperatures will be slightly higher than today.
A Quebec man has missed out on winning millions on the Canadian lottery, because his ticket was printed out seven seconds too late.
The dramatic moment that Dutch police stormed a TV studio to arrest a gunman was caught on the station's cameras.