There are no immediate reports of injuries relating to the explosions and fire in Belper, the Derby Telegraph reports citing local emergency services.
It also reported that people in the area are being advised to stay indoors to avoid breathing the air around the factory.
More top news
A great-grandmother who completed a skydive to raise money for the hospice which cared for her husband has vowed to do it again at 90.
Urban Outfitters has apologised for a 'red-stained' sweater bearing the logo of a US university where four students were shot dead in 1970.
Edinburgh's poet laureate has offered some words of reconciliation as Scotland prepares to vote on independence in just two days' time.