Angelina's openness in talking about her own experience and her decision to have surgery raises crucial awareness of breast cancer and its genetic risk.
Deciding whether to have preventative surgery is a heart-rending decision for women like Angelina but we know it's a vital way of saving lives.
This is a stark reminder of how much more research we need to do to give women more knowledge, choice and life-saving options to reduce their risk.
If you are at all concerned that you may have an inherited mutation in your family and want further advice, your GP will be able to provide more information and help.
Brad Pitt described his partner Angelina Jolie as "absolutely heroic" after the actress revealed she underwent a double mastectomy.
Breast cancer charities warn that all women should be "breast aware" - but what should you look out for?
As Angelina Jolie reveals she underwent a preventative double mastectomy, Tracey Barraclough tells ITV News why she had the same procedure.