Asked for David Cameron's response to Sir David Nicholson's retirement and assessment of his record, the Prime Minister's official spokesman said: "He agrees with the Secretary of State for Health."
Mr Cameron's view of Sir David was "unchanged" since the PM responded to the Francis report on Mid-Staffordshire, said the spokesman.
He said he was not aware of ministers discussing the NHS chief's departure with Sir David in advance, adding: "It is his decision to retire."
More top news
Donald Trump's revised immigration ban targets the same seven Muslim majority countries listed in his original executive order, sources say.
People convicted of cruelty against animals should face much harsher prison sentences, some charities have claimed.
Theresa May has been warned by EU ministers that Britain's Brexit negotiators must be prepared to compromise or risk a "crash landing".