Asked for David Cameron's response to Sir David Nicholson's retirement and assessment of his record, the Prime Minister's official spokesman said: "He agrees with the Secretary of State for Health."
Mr Cameron's view of Sir David was "unchanged" since the PM responded to the Francis report on Mid-Staffordshire, said the spokesman.
He said he was not aware of ministers discussing the NHS chief's departure with Sir David in advance, adding: "It is his decision to retire."
More top news
Former Girls Aloud singer Kimberley Walsh is pregnant with her second child, she has revealed.
Chancellor George Osborne will seek to reassure financial markets on Monday morning following Britain's decision to leave the EU.
In his first outing since the referendum result, the lead Leave campaigner has outlined his vision for a post-Brexit Britain.