David Cameron said he believed the terms of UK's membership of the European Union would be successfully renegotiated, during an interview with BBC Radio 4.
The Prime Minister said his policy on Europe was the "boldest", "clearest" and "most straightforward" a leader has had for 30 years.
Mr Cameron added: "I don't accept the narrative that says the only way Britain can succeed is to pull up the drawbridge."
More top news
In a series of tweets, the US president says transgender people will not allowed or accepted to serve their country 'in any capacity'.
The chancellor - having won the argument within Cabinet - has told ITV News he is targeting a swift start to talks on the interim deal.
Moving footage of eight-year-old Saffie Roussos has been released by her family as her funeral took place.