The Deputy Prime Minister will say that Tory backbenchers are "consumed by game playing" after a week dominated by revolts over Europe and gay marriage.
He will however dismiss talks of a an early break-up between the Conservatives and Liberal Democrats, during a speech in Westminster.
Speculation over the coalition's future was fuelled this weekend when the Prime Minister raised in an interview the prospect of governing alone.
Mr Cameron told Total Politics magazine that despite some "frustrations", the coalition remained the best way to get things done.
"But if that wasn't the case then we'd have to face the new circumstances in whatever way we should,' he added.
More top news
Former Israeli president Shimon Peres dies, aged 93, following a stroke two weeks ago.
The eight foot bronze statue coincides with the 75th anniversary of Eric Morecambe and Ernie Wise first appearing on stage together.
Britney Spears sung hits from all nine of her albums during her highly-anticipated appearance at the Apple Music Festival in London.