The nation's first Wetherspoon motorway pub will open at the Extra service station on the M40 near Beaconsfield, around four miles outside the capital's M25 ring road.
Extra's website describes it as "one of the newest and most attractive Motorway Service Areas in Europe".
The £2 million development has been given the go-ahead by Thames Valley Police and South Bucks District Council.
As part of its application, JD Wetherspoon said the pub would display notices reminding customers of the dangers of drink-driving, although a spokesman said bar staff would not ask customers whether they were driving.
More top news
Protestors angry about an immigration raid at Byron burger earlier this week reacted by launching hundreds of insects into the restaurant
Families and rebel fighters are believed to be among the people to have left besieged Aleppo on Saturday through safe corridors.
The balloon came down near Lockhart, Texas, around 8.30am local time.