The nation's first Wetherspoon motorway pub will open at the Extra service station on the M40 near Beaconsfield, around four miles outside the capital's M25 ring road.
Extra's website describes it as "one of the newest and most attractive Motorway Service Areas in Europe".
The £2 million development has been given the go-ahead by Thames Valley Police and South Bucks District Council.
As part of its application, JD Wetherspoon said the pub would display notices reminding customers of the dangers of drink-driving, although a spokesman said bar staff would not ask customers whether they were driving.
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