The nation's first Wetherspoon motorway pub will open at the Extra service station on the M40 near Beaconsfield, around four miles outside the capital's M25 ring road.
Extra's website describes it as "one of the newest and most attractive Motorway Service Areas in Europe".
The £2 million development has been given the go-ahead by Thames Valley Police and South Bucks District Council.
As part of its application, JD Wetherspoon said the pub would display notices reminding customers of the dangers of drink-driving, although a spokesman said bar staff would not ask customers whether they were driving.
More top news
The last day of the inquiry into Alexander Litvinenko's murder has heard that Vladimir Putin should be held responsible for his death.
American philanthropists have pledged to match new donations up to $100,000 to the research team who had been tracking Cecil since 2008.
As our Changing Minds series on mental health comes to an end, we take a look back at the stories which made the news this week.