Susan Rice, the US ambassador to the UN who pulled out of the race for Secretary of State for fear of "politicising" the process, has landed one of the key roles under Barack Obama.
She will be named the President's new national security adviser after Tom Donilon resigned the post, the Associated Press has reported, citing a source.
Ms Rice withdrew from the Secretary of State contest in a letter in December, fearing her nomination would be "lengthy, disruptive and costly". The role later went to John Kerry.
Ms Rice had angered opposition Republican senators with comments she made following the attack on the US consulate in the Libyan city of Benghazi last September.