Health Secretary Jeremy Hunt has described the mortality rate between north and south as a "shocking variation".
The Health Secretary said: "This shocking variation in early and unnecessary deaths means people's lives are needlessly cut short and that cannot continue unchecked.
"I want areas to use the data released today to identify local public health challenges like smoking, drinking and obesity and to take action to help achieve our ambition for saving 30,000 lives a year by 2020."
More top news
Former Girls Aloud singer Kimberley Walsh is pregnant with her second child, she has revealed.
Chancellor George Osborne will seek to reassure financial markets on Monday morning following Britain's decision to leave the EU.
In his first outing since the referendum result, the lead Leave campaigner has outlined his vision for a post-Brexit Britain.