A tweet from the New York City Fire Department says that the two workers are trapped on the 45th floor - one level short of the roof.
NBC New York reports that 60 fire officers are attending the scene.
More top news
Plenty of dry weather around, although the odd spot of rain for a few. Not as cold overnight as it has been.
A young boy who got his head stuck in a child's toilet seat had to be cut free by firefighters.
Labour's Harriet Harman has urged the Prime Minister to take in more Syrian refugees saying the UK should not shirk its responsibility.