All air and sea ports have been put on alert for missing 14-year-old girl and 35-year-old John Bush.
Police say sightings suggest they are heading south from Yorkshire and that any move to leave the country would be "very foolish".
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Prince William flew a woman critically injured in a collision involving a police van to hospital during his final air ambulance pilot shift.
The train was severely damaged after ploughing into buffers at a busy station in the city's northeast in the early hours of Friday morning.
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