Egyptian President Mohammed Morsi has said Egypt has decided to cut all ties with Syria and will withdraw the country's envoy from Damascus.
Addressing a gathering of Sunni Muslim clerics in Cairo, Morsi said: "We decided today to entirely break off relations with Syria and with the current Syrian regime."
He also warned Assad's allies in the Iranian-backed Lebanese Shi'ite militia to pull back from fighting in Syria.
"We stand against Hezbollah in its aggression against the Syrian people," Morsi said.
"Hezbollah must leave Syria - these are serious words. There is no space or place for Hezbollah in Syria."
US President Barack Obama has tip-toed over the 'red-line' and armed Syrian rebels but it is a gamble of huge proportions.
Writing for ITV News, international affairs analyst David Butter looks at the timing of US support for Syria and when it may arrive.
Are the US supplied assault rifles too little, too late and what incentive is there for Assad to enter peace talks?